[在通过细胞病变效应进行病毒滴定的中和试验中交叉吸收血清的应用]
[Use of cross-absorbed sera in neutralization tests with viral titration by the cytopathogenic effect].
作者信息
Pervikov Iu V, Chumakov M P, Voroshilova M K, Rubin S G
出版信息
Vopr Virusol. 1975 May-Jun(3):309-12.
PMID:169628
Abstract
A new method for intratypic antigenic differentiation of poliovirus strains has been developed. The method is based on the use of cross-absorbed sera in neutralization tests where virus is titrated by the cytopathic effect. Qualitative differences between the antigenic structure of vaccine and "wild" strains as well as between some "wild" strains of the same serologic type have been found. The method may be used in practical laboratories.
摘要
已开发出一种脊髓灰质炎病毒株型内抗原分化的新方法。该方法基于在中和试验中使用交叉吸收血清，其中通过细胞病变效应滴定病毒。已发现疫苗株和“野生”株的抗原结构之间以及同一血清型的一些“野生”株之间存在定性差异。该方法可用于实际实验室。
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