孕期使用利妥昔单抗治疗对新生儿的影响。
The effects of rituximab treatment during pregnancy on a neonate.
作者信息
Friedrichs Birte, Tiemann Markus, Salwender Hans, Verpoort Karl, Wenger Michael K, Schmitz Norbert
出版信息
Haematologica. 2006 Oct;91(10):1426-7. Epub 2006 Sep 7.
PMID:16963391
Abstract
A 35-year old woman developed Burkitt's lymphoma and was treated with rituximab and CHOP therapy early during pregnancy. Monitoring of rituximab concentrations and B-cell counts in the child revealed a transient complete B-cell depletion associated with high rituximab cord blood concentrations. B-cell recovery was fast, showing a regular immunophenotype without loss of CD20 antigen, no functional deficits and adequate vaccination IgG titers.
摘要
一名35岁女性患伯基特淋巴瘤，在妊娠早期接受了利妥昔单抗和CHOP疗法治疗。对患儿的利妥昔单抗浓度和B细胞计数监测显示，与脐带血中高浓度利妥昔单抗相关的短暂性完全B细胞耗竭。B细胞恢复迅速，表现出正常的免疫表型，无CD20抗原丢失，无功能缺陷，疫苗接种后的IgG滴度充足。
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