Nuyts R M, Edelhauser H F, Pels E, Breebaart A C
Department of Ophthalmology, University of Amsterdam, The Netherlands.
Arch Ophthalmol. 1990 Aug;108(8):1158-62. doi: 10.1001/archopht.1990.01070100114045.
Eighteen patients developed a toxic endothelial cell destruction syndrome following normal intraocular surgery, caused by a detergent residue originating from irrigating cannulas. The residue occurred after the concentration of a detergent solution has been increased from 0.4% to 4%, in combination with insufficient cleaning of the cannulas. Mass spectrometric analysis revealed the detergent to contain a nonionic ethoxylated fatty alcohol (6% vol/vol). Quantitative endothelial vital staining and in vitro corneal endothelial perfusion demonstrated endothelial toxic effects at the 1% and 0.06% level for the detergent and the pure ethoxylated fatty alcohol, respectively. Permeability studies showed that the toxic effects occurred as a result of endothelial barrier breakdown.
18名患者在正常眼内手术后出现了毒性内皮细胞破坏综合征，这是由冲洗套管中的洗涤剂残留所致。在洗涤剂溶液浓度从0.4%提高到4%且套管清洁不足的情况下出现了残留。质谱分析显示该洗涤剂含有一种非离子乙氧基化脂肪醇（体积分数为6%）。定量内皮细胞活体染色和体外角膜内皮灌注显示，洗涤剂和纯乙氧基化脂肪醇分别在1%和0.06%的浓度水平时具有内皮毒性作用。通透性研究表明，毒性作用是由于内皮屏障破坏所致。
