Carlson Scott R, Iacono William G
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Psychophysiology. 2006 Sep;43(5):470-80. doi: 10.1111/j.1469-8986.2006.00450.x.
Early adulthood is a period of late brain development corresponding to the age of onset for psychopathology associated with P300 amplitude reductions. Although amplitude from a single occasion is heritable, little is known about genetic influences on change during this period. This is the first study of P300 change to combine latent growth and twin models. P300 at Pz was measured up to three times at approximately ages 17, 20, and 23 in monozygotic and dizygotic male twins using a visual task. P300 decreased with age. Correlations indexing the stability of amplitude over time were high (median r=.72) and almost 90% of the stable variance (i.e., the model intercept) was attributable to genetic influences. The rate of decrease was heritable, and the genes influencing intercept may be the same ones influencing change. Finally, intercept was more heritable than amplitude at any single time point. Intercept may be a more useful aid in the search for genes associated with relevant psychopathology than single measures of P300. Over a broader age range growth indices may be useful "developmental" endophenotypes.
成年早期是大脑发育后期的一个阶段，与P300波幅降低相关的精神病理学发病年龄相对应。尽管单次测量的波幅具有遗传性，但对于这一时期变化的遗传影响知之甚少。这是第一项将潜在生长模型和双生子模型结合起来研究P300变化的研究。使用视觉任务，在大约17岁、20岁和23岁时，对同卵和异卵男性双胞胎的Pz点的P300进行了多达三次的测量。P300随年龄下降。表示波幅随时间稳定性的相关性很高（中位数r = 0.72），并且几乎90%的稳定方差（即模型截距）可归因于遗传影响。下降速率具有遗传性，影响截距的基因可能与影响变化的基因相同。最后，截距比任何单个时间点的波幅遗传性更强。在寻找与相关精神病理学相关的基因方面，截距可能比P300的单次测量更有用。在更广泛的年龄范围内，生长指数可能是有用的“发育性”内表型。
