Pinto A J, Morahan P S, Brinton M, Stewart D, Gavin E
Department of Microbiology and Immunology, Medical College of Pennsylvania, Philadelphia 19129.
J Interferon Res. 1990 Jun;10(3):293-8. doi: 10.1089/jir.1990.10.293.
Recombinant (r) preparations of interferons (IFN)-alpha, -beta, and -gamma were shown to protect mice against experimental virus infections with herpes simplex virus type 2 (HSV-2), and with three RNA-containing viruses from different families: Banzi, a flavivirus; Semliki Forest virus (SFV), an alphatogavirus; and Caraparu, a bunyavirus. The antiviral effects of the three different types of IFN were different with each virus. HSV-2 was the most sensitive virus, followed by SFV. Against Banzi virus, IFN-gamma was only effective when given both before and after infection. Against Caraparu virus, only IFN-gamma had a significant effect. These results suggest that IFN therapy might be valuable in human infections with these viruses, but that the correct choice of IFN and dose regimen is likely to be important.
重组α、β和γ干扰素制剂已被证明能保护小鼠免受2型单纯疱疹病毒（HSV - 2）以及来自不同科的三种含RNA病毒的实验性病毒感染：黄病毒科的班齐病毒、甲病毒科的Semliki森林病毒（SFV）和布尼亚病毒科的卡拉帕鲁病毒。三种不同类型的干扰素对每种病毒的抗病毒效果不同。HSV - 2是最敏感的病毒，其次是SFV。对于班齐病毒，γ干扰素仅在感染前和感染后给药时才有效。对于卡拉帕鲁病毒，只有γ干扰素具有显著效果。这些结果表明，干扰素疗法可能对人类感染这些病毒有价值，但正确选择干扰素和给药方案可能很重要。
