Affolter V K, Moore P F
Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA.
Vet Pathol. 2006 Sep;43(5):646-55. doi: 10.1354/vp.43-5-646.
Histiocytic proliferative diseases include reactive and neoplastic proliferations of dendritic cells (DC) or macrophages. Various forms of DC proliferations have been documented in humans and dogs; their etiology is largely unknown. With the exception of a few case reports, histiocytic proliferations have not been characterized in cats. This study summarizes clinical, morphologic, and immunophenotypic features of a feline progressive histiocytosis (FPH) in 30 cats. There was no breed or age predilection. Females were more often affected than males. Solitary or multiple nonpruritic firm papules, nodules, and plaques had a predilection for feet, legs, and face. Lesions consisted of poorly circumscribed epitheliotropic (13/30) and nonepitheliotropic (17/30) histiocytic infiltrates of the superficial and deep dermis, with variable extension into the subcutis. The histiocytic population was relatively monomorphous early in the clinical course. With disease progression, cellular pleomorphism was more frequently encountered. Histiocytes expressed CD1a, CD1c, CD18, and major histocompatibility complex class II molecules. This immunophenotype suggests a DC origin of these lesions. Coexpression of E-cadherin, a feature of cutaneous Langerhans cells, was only observed in 3 cats. FPH followed a progressive clinical course; the lesions, however, were limited to the skin for an extended period of time. Terminal involvement of internal organs was documented in 7 cases. Treatment with chemotherapeutics or immunosuppressive and immunomodulatory drugs was not successful. The etiology of FPH remains unknown. FPH is best considered an initially indolent cutaneous neoplasm, which is mostly slowly progressive and may spread beyond the skin in the terminal stage.
组织细胞增生性疾病包括树突状细胞（DC）或巨噬细胞的反应性和肿瘤性增生。在人类和犬类中已记录到多种形式的DC增生；其病因大多不明。除了少数病例报告外，猫的组织细胞增生尚未得到特征描述。本研究总结了30只猫的猫进行性组织细胞增多症（FPH）的临床、形态学和免疫表型特征。无品种或年龄偏好。雌性比雄性更常受累。孤立或多发的非瘙痒性坚实丘疹、结节和斑块好发于足部、腿部和面部。病变由浅表和深部真皮界限不清的亲上皮性（13/30）和非亲上皮性（17/30）组织细胞浸润组成，不同程度地延伸至皮下组织。在临床病程早期，组织细胞群体相对单一。随着疾病进展，细胞多形性更常见。组织细胞表达CD1a、CD1c、CD18和主要组织相容性复合体II类分子。这种免疫表型提示这些病变起源于DC。E-钙黏蛋白的共表达是皮肤朗格汉斯细胞的一个特征，仅在3只猫中观察到。FPH呈进行性临床病程；然而，病变在很长一段时间内仅限于皮肤。7例记录有内脏终末期受累。化疗或免疫抑制及免疫调节药物治疗均未成功。FPH的病因仍然不明。FPH最好被认为是一种最初进展缓慢的皮肤肿瘤，大多进展缓慢，在终末期可能扩散至皮肤以外。
