Wirkas Theo, Toikilik Steven, Miller Nan, Morgan Chris, Clements C John
National Department of Health, Port Moresby, Papua, New Guinea.
Vaccine. 2007 Jan 8;25(4):691-7. doi: 10.1016/j.vaccine.2006.08.028. Epub 2006 Aug 31.
Fourteen data loggers were packed with vaccine vials at the national vaccine store, Port Moresby, Papua New Guinea (PNG), and sent to peripheral locations in the health system. The temperatures that the data loggers recorded during their passage along the cold chain indicated that heat damage was unlikely, but that all vials were exposed to freezing temperatures at some time. The commonest place where freezing conditions existed was during transport. The freezing conditions were likely induced by packing the vials too close to the ice packs that were themselves too cold, and with insufficient insulation between them. This situation was rectified and a repeat dispatch of data loggers demonstrated that the system had indeed been rectified. Avoiding freeze damage becomes even more important as the price of freeze-sensitive vaccines increases with the introduction of more multiple-antigen vaccines. This low-cost high-tech method of evaluating the cold chain function is highly recommended for developing and industrialized nations and should be used on a regular basis to check the integrity of the vaccine cold chain. The study highlights the need for technological solutions to avoid vaccine freezing, particularly in hot climate countries.
在巴布亚新几内亚莫尔斯比港的国家疫苗库中，14个数据记录器与疫苗瓶一同包装，并被送往卫生系统的周边地点。数据记录器在冷链运输过程中记录的温度表明，疫苗不太可能受到热损伤，但所有疫苗瓶在某些时候都暴露在冰点温度下。存在结冰情况最常见的地方是在运输过程中。结冰情况可能是由于疫苗瓶包装得离本身温度过低的冰袋太近，且它们之间的隔热材料不足所致。这种情况得到了纠正，再次发送数据记录器的结果表明系统确实已得到整改。随着对温度敏感的疫苗价格随着更多多抗原疫苗的推出而上涨，避免冻害变得更加重要。这种评估冷链功能的低成本高科技方法强烈推荐给发展中国家和工业化国家，并且应该定期使用以检查疫苗冷链的完整性。该研究强调了需要技术解决方案来避免疫苗冻结，特别是在炎热气候的国家。
