Abbracchio Maria P, Burnstock Geoffrey, Boeynaems Jean-Marie, Barnard Eric A, Boyer José L, Kennedy Charles, Knight Gillian E, Fumagalli Marta, Gachet Christian, Jacobson Kenneth A, Weisman Gary A
Department of Pharmacological Sciences, University of Milan, Milan, Italy.
Pharmacol Rev. 2006 Sep;58(3):281-341. doi: 10.1124/pr.58.3.3.
There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptor subtypes have been cloned and characterized and most orphan receptors de-orphanized, so that it is now possible to provide a basis for a future subdivision of P2Y receptor subtypes. More is known about the functional elements of the P2Y receptor molecules and the signaling pathways involved, including interactions with ion channels. There have been substantial developments in the design of selective agonists and antagonists to some of the P2Y receptor subtypes. There are new findings about the mechanisms underlying nucleotide release and ectoenzymatic nucleotide breakdown. Interactions between P2Y receptors and receptors to other signaling molecules have been explored as well as P2Y-mediated control of gene transcription. The distribution and roles of P2Y receptor subtypes in many different cell types are better understood and P2Y receptor-related compounds are being explored for therapeutic purposes. These and other advances are discussed in the present review.
自我们国际药理学联合会小组委员会发表上次综述以来，我们对P2Y受体信号传导不同方面的认识有了许多进展。更多的受体亚型已被克隆和表征，大多数孤儿受体也已找到对应的配体，因此现在有可能为未来P2Y受体亚型的细分提供依据。我们对P2Y受体分子的功能元件和所涉及的信号通路有了更多了解，包括与离子通道的相互作用。针对某些P2Y受体亚型的选择性激动剂和拮抗剂的设计有了实质性进展。关于核苷酸释放和胞外核苷酸分解的潜在机制有了新的发现。已经探索了P2Y受体与其他信号分子受体之间的相互作用以及P2Y介导的基因转录调控。人们对P2Y受体亚型在许多不同细胞类型中的分布和作用有了更好的理解，并且正在探索与P2Y受体相关的化合物用于治疗目的。本综述将讨论这些以及其他进展。
