Kagawa Isamu, Nishiwaki Kohichi, Matsumoto Yoshiro, Ohi Akifumi
Dept. of Surgery, Asada General Hospital.
Gan To Kagaku Ryoho. 2006 Oct;33(10):1465-8.
A 75-year-old man was admitted to our hospital with hematoemesis. Gastrofiber-scopy revealed that type 3 gastric cancer was widespread in the lesser curvature. Multiple liver metastases 5 cm in diameter were shown on CT. We thought that the case was unresectable, and TS-1/CDDP chemotherapy was performed. TS-1 (80 mg/body/day) was orally administered and CDDP at 20 mg/body/day by intravenous drip infusion a week for 3 weeks followed by a drug-free 2 week period as the first course. After the third course, the primary lesion and the liver metastasis showed a partial response in terms of size. No serious drug adverse reaction was observed. Since there was no longer any reduction of the tumor, gastrectomy and coagulation therapy for liver metastasis were performed, and he has been alive for 15 months without recurrence. Combined use of TS-1 and CDDP is effective as neoadjuvant chemotherapy for advanced gastric cancer.
一名75岁男性因呕血入院。胃镜检查显示，3型胃癌广泛分布于胃小弯处。CT显示有多个直径5厘米的肝转移灶。我们认为该病例无法切除，遂进行了替吉奥/顺铂化疗。替吉奥（80毫克/体/天）口服给药，顺铂20毫克/体/天静脉滴注，每周1次，共3周，随后停药2周作为第一个疗程。第三个疗程后，原发灶和肝转移灶在大小方面显示出部分缓解。未观察到严重的药物不良反应。由于肿瘤不再缩小，遂进行了胃切除术和肝转移灶的凝固治疗，患者已存活15个月且无复发。替吉奥和顺铂联合使用作为晚期胃癌的新辅助化疗是有效的。
