Tae Woo Suk, Hong Seung Bong, Joo Eun Yun, Han Sun Jung, Cho Jae-Wook, Seo Dae Won, Lee Jong-Min, Kim In Young, Byun Hong Sik, Kim Sun I
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Korean J Radiol. 2006 Jul-Sep;7(3):162-72. doi: 10.3348/kjr.2006.7.3.162.
We aimed to find structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients.
The volumes of the cerebrum, hippocampus and frontal lobe and the area of the corpus callosum's subdivisions were all semiautomatically measured, and then optimized voxel-based morphometry (VBM) was performed in 19 JME patients and 19 age/gender matched normal controls.
The rostrum and rostral body of the corpus callosum and the left hippocampus were significantly smaller than those of the normal controls, whereas the volume of the JME's left frontal lobe was significantly larger than that of the controls. The area of the rostral body had a significant positive correlation with the age of seizure onset (r = 0.56, p = 0.012), and the volume of the right frontal lobe had a significant negative correlation with the duration of disease (r = -0.51, p = 0.025). On the VBM, the gray matter concentration of the prefrontal lobe (bilateral gyri rectus, anterior orbital gyri, left anterior middle frontal gyrus and right anterior superior frontal gyrus) was decreased in the JME group (corrected p < 0.05).
The JME patients showed complex structural abnormalities in the corpus callosum, frontal lobe and hippocampus, and also a decreased gray matter concentration of the prefrontal region, which all suggests there is an abnormal neural network in the JME brain.
我们旨在发现青少年肌阵挛癫痫（JME）患者大脑结构异常。
对大脑、海马体和额叶的体积以及胼胝体各亚区的面积进行半自动测量，然后对19例JME患者和19名年龄/性别匹配的正常对照者进行优化的基于体素的形态学测量（VBM）。
胼胝体的嘴部和嘴侧体部以及左侧海马体明显小于正常对照者，而JME患者左侧额叶的体积明显大于对照者。嘴侧体部的面积与癫痫发作起始年龄呈显著正相关（r = 0.56，p = 0.012），右侧额叶的体积与病程呈显著负相关（r = -0.51，p = 0.025）。在VBM分析中，JME组前额叶（双侧直回、眶前回、左侧额中回前部和右侧额上回前部）的灰质浓度降低（校正p < 0.05）。
JME患者在胼胝体、额叶和海马体表现出复杂的结构异常，前额叶区域的灰质浓度也降低，这均提示JME患者大脑存在神经网络异常。
