Qian Yue-sheng, Zhang Yi, Zhang Wei-zhong
Shanghai Institute of Hypertension, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Aug;26(8):698-701.
To investigate the relationship between the polymorphism of alpha-adducin (ADD1) gene and the two phenotypes of constitution in patients with essential hypertension, the Yang-hyperactive (YH) type and phlegm-dampness (PD) type, classified by traditional Chinese medicine (TCM) approach.
Two hundred and seven patients differentiated by TCM approach as YH type (113 cases) or PD type (94 cases) were observed, with the systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), fasting blood glucose (FBG), serum creatinine (Cr), uric acid (UA), total cholesterol (TC) and triglycerides (TG) as the criteria of observation. Gly460Trp polymorphism of the ADD1 gene was detected by MALDI-TOF mass spectrometry. Results The levels of BMI, DBP, FBG and UA, etc. in the PD group were significantly higher than those in the YH group respectively. The rate of GG, GT and TT type of ADD1 gene was 29.2%, 41.6% and 29.2% in the YH group, 28.7%, 48.9% and 22.3% in the PD group, showing no significant difference in ADD1 genotype distribution between the two groups, while there was also no difference in the hypertension phenotype distribution among different genotypes (both P > 0.05). For the patients with TT genotype, there were significant differences between the YH group and the PD group in BMI (24.11 +/- 3.04 kg/m2 vs 26.20 +/- 2.30 kg/m2), DBP (96.79 +/- 4.05 mmHg vs 99.56 +/- 3.90 mmHg), FBG (5.01 +/- 0.53 mmol/L vs 5.51 +/- 1.07 mmol/L) and UA level (302.22 +/- 71.95 micromol/L vs 358.25 +/- 88.75 micromol/L, all P < 0.05).
There was no relation between ADD1 gene polymorphism and the TCM genotype of constitution in patients with essential hypertension. However, it is likely that for hypertension patients with TT genotype, those of PD type are more susceptible to cardiovascular disease and have worse prognosis than those of YH type.
采用中医方法探讨原发性高血压患者中阳盛（YH）型和痰湿（PD）型两种体质类型与α-内收蛋白（ADD1）基因多态性的关系。
观察207例经中医辨证为YH型（113例）或PD型（94例）的患者，以收缩压（SBP）、舒张压（DBP）、体重指数（BMI）、空腹血糖（FBG）、血清肌酐（Cr）、尿酸（UA）、总胆固醇（TC）和甘油三酯（TG）作为观察指标。采用基质辅助激光解吸电离飞行时间质谱法检测ADD1基因的Gly460Trp多态性。结果PD组的BMI、DBP、FBG和UA等水平分别显著高于YH组。ADD1基因的GG、GT和TT型频率在YH组分别为29.2%、41.6%和29.2%，在PD组分别为28.7%、48.9%和22.3%，两组间ADD1基因型分布无显著差异，不同基因型间高血压体质类型分布也无差异（均P>0.05）。对于TT基因型患者，YH组和PD组在BMI（24.11±3.04kg/m² vs 26.20±2.30kg/m²）、DBP（96.79±4.05mmHg vs 99.56±3.90mmHg）、FBG（5.01±0.53mmol/L vs 5.51±1.07mmol/L）和UA水平（302.22±71.95μmol/L vs 358.25±88.75μmol/L，均P<0.05）方面存在显著差异。
原发性高血压患者ADD1基因多态性与中医体质基因型无关。然而，对于TT基因型的高血压患者，PD型患者可能比YH型患者更容易患心血管疾病且预后更差。
