α-内收蛋白Gly460Trp多态性与高血压男性运动的降压效果

The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure.

作者信息

Pescatello Linda S, Blanchard Bruce E, Tsongalis Gregory J, Maresh Carl M, O'Connell Ann, Thompson Paul D

机构信息

Department of Kinesiology, University of Connecticut, Storrs, CT, USA.

出版信息

Clin Sci (Lond). 2007 Sep;113(5):251-8. doi: 10.1042/CS20060345.

DOI:10.1042/CS20060345

PMID:17472579

Abstract

The alpha-adducin Gly460Trp polymorphism alters renal sodium transport and is associated with hypertension. Despite the immediate sodium- and volume-depleting effects of aerobic exercise, the influence of the alpha-adducin Gly460Trp polymorphism on PEH (postexercise hypotension) has not been studied. In the present study we examined the effects of the alpha-adducin Gly460Trp polymorphism on PEH among 48 men (42.6+/-1.6 years; mean+/-S.E.M.) with high BP (blood pressure; 144.0+/-1.7/84.7+/-1.1 mmHg). Subjects completed three experiments: non-exercise control and two cycle exercise sessions at 40% (light exercise) and 60% (moderate exercise) of maximal oxygen consumption. Subjects left the laboratory wearing an ambulatory BP monitor. PCR and restriction enzyme digestion determined the genotypes. No subjects had the Trp460Trp genotype due to the low frequency of 5% in the population. Repeated measure ANCOVA tested whether BP differed over time between experimental conditions and genotypes (Gly460Gly, n=36; Gly460Trp, n=12). Among Gly460Gly genotypes, SBP (systolic BP) was reduced by 5.2+/-1.4 mmHg after moderate exercise compared with non-exercise controls over 9 h (P<0.01). Among Gly460Trp genotypes, SBP was lowered by 7.8+/-2.3 mmHg; after light exercise compared with non-exercise controls over 9 h (P<0.05). The SBP reductions after light exercise (0.6+/-1.3 compared with 7.8+/-2.3 mmHg; P<0.05) but not moderate exercise (5.2+/-1.4 compared with 3.8+/-2.4 mmHg; P> or =0.05) differed between the Gly460Gly and Gly460Trp genotypes respectively. Men with Gly460Gly had a reduced SBP after moderate exercise, whereas men with Gly460Trp had a reduced SBP after light exercise. However, only the SBP reductions after light exercise differed between genotypes. Our findings indicate that the alpha-adducin Gly460Trp genotype may be useful in identifying men who have a reduced BP after lower intensity aerobic exercise.

摘要

α - 内收蛋白Gly460Trp多态性改变肾脏钠转运并与高血压相关。尽管有氧运动有直接的排钠和减少血容量的作用，但α - 内收蛋白Gly460Trp多态性对运动后低血压（PEH）的影响尚未得到研究。在本研究中，我们在48名高血压（血压为144.0±1.7/84.7±1.1 mmHg）男性（42.6±1.6岁；平均值±标准误）中研究了α - 内收蛋白Gly460Trp多态性对PEH的影响。受试者完成了三项实验：非运动对照以及两次分别以最大耗氧量的40%（轻度运动）和60%（中度运动）进行的自行车运动实验。受试者离开实验室时佩戴动态血压监测仪。通过聚合酶链反应（PCR）和限制性内切酶消化确定基因型。由于该基因型在人群中的频率低至5%，没有受试者具有Trp460Trp基因型。重复测量协方差分析用于检验实验条件和基因型（Gly460Gly，n = 36；Gly460Trp，n = 12）之间血压随时间是否存在差异。在Gly460Gly基因型中，与非运动对照相比，中度运动后9小时收缩压（SBP）降低了5.2±1.4 mmHg（P<0.01）。在Gly460Trp基因型中，与非运动对照相比，轻度运动后9小时SBP降低了7.8±2.3 mmHg（P<0.05）。轻度运动后SBP降低幅度在Gly460Gly和Gly460Trp基因型之间存在差异（0.6±1.3与7.8±2.3 mmHg相比；P<0.05），而中度运动后则无差异（5.2±1.4与3.8±2.4 mmHg相比；P≥0.05）。Gly460Gly基因型男性在中度运动后SBP降低，而Gly460Trp基因型男性在轻度运动后SBP降低。然而，只有轻度运动后SBP降低幅度在基因型之间存在差异。我们的研究结果表明，α - 内收蛋白Gly460Trp基因型可能有助于识别在低强度有氧运动后血压降低的男性。