Wang Lifang, Zheng Bin, Zhao Hongguang, Du Peng, Sun Aihua, Hua Kouzhen, Gao Yuyu
Zhejiang Cancer Hospital, Hangzhou, China.
Indian J Med Res. 2014 Feb;139(2):273-8.
BACKGROUND & OBJECTIVES: The association between α-adducin gene G614T polymorphism and essential hypertension (EH) is not clear. The present study was carried out to examine a possible association between α-adducin gene G614T mutation and essential hypertension in Chinese population.
A total of 170 patients with essential hypertension (EH group) and 154 normotensive subjects (Control group) were genotyped for the cytoskeletal protein single nucleotide polymorphism G614T of the α-adducin gene by PCR-RFLP technique. Systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), low density lipoprotein (LDL), high-density lipoprotein (HDL), high-sensitivity C-reactive protein (hs-CRP), left atrial diameter (LA DIA), left ventricular diameter (LV DIA) and other parameters were recorded in EH group.
There was significant association between EH and α-adducin genotypes (P<0.05). GT and TT genotypes in EH group had higher LDL levels as compared to GG carriers (P<0.05). The LDL concentration was significantly elevated in patients with GT and TT genotypes. The LDL levels also differed significantly in male patients with all the three genotypes.
INTERPRETATION & CONCLUSIONS: A significant association was found between ADD1 gene G614T polymorphism and EH in Chinese patients. Further studies need to be done to confirm these findings in a large sample.
α-内收蛋白基因G614T多态性与原发性高血压（EH）之间的关联尚不清楚。本研究旨在探讨α-内收蛋白基因G614T突变与中国人群原发性高血压之间的可能关联。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，对170例原发性高血压患者（EH组）和154例血压正常者（对照组）进行细胞骨架蛋白单核苷酸多态性G614T的基因分型。EH组记录收缩压（SBP）、舒张压（DBP）、体重指数（BMI）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、高敏C反应蛋白（hs-CRP）、左房内径（LA DIA）、左室内径（LV DIA）等参数。
EH与α-内收蛋白基因分型之间存在显著关联（P<0.05）。与GG携带者相比（P<0.05），EH组的GT和TT基因型LDL水平更高。GT和TT基因型患者的LDL浓度显著升高。三种基因型男性患者的LDL水平也有显著差异。
在中国患者中发现ADD1基因G614T多态性与EH之间存在显著关联。需要进一步研究以在大样本中证实这些发现。
