鞘内注射spantide II对大鼠的抗伤害感受和P物质拮抗作用：无运动功能损害或神经毒性迹象。

Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity.

作者信息

Wiesenfeld-Hallin Z, Xu X J, Kristensson K, Håkanson R, Feng D M, Folkers K

机构信息

Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.

出版信息

Regul Pept. 1990 Jun;29(1):1-11. doi: 10.1016/0167-0115(90)90104-5.

DOI:10.1016/0167-0115(90)90104-5

PMID:1697080

Abstract

The effect of intrathecally (i.t.) applied substance P (SP) analogue, (D-NicLys1,3-Pal3,D-Cl2Phe5,Asn6,D-Trp7,9,Nle 11)-SP (Spantide II), was examined in rats. Spantide II even at a high dose (10 micrograms) did not evoke any behavioural responses and caused no motor disturbances, but it did have a brief antinociceptive effect on the hot-plate test. Spantide II dose-dependently reduced the caudally directed scratching/biting behaviour, evoked by 1 microgram i.t. SP for over 30 min, but did not block the caudally directed scratching behaviour evoked by i.t. somatostatin. Histological examination revealed no pathological changes in the spinal cord after treatment with Spantide II. The results indicate that Spantide II is an effective tachykinin antagonist in the central nervous system and that it causes no neural damage.

摘要

在大鼠中研究了鞘内（i.t.）应用P物质（SP）类似物（D-尼克赖氨酸1,3-棕榈酰3，D-氯苯丙氨酸5，天冬酰胺6，D-色氨酸7,9，Nle 11）-SP（Spantide II）的作用。Spantide II即使在高剂量（10微克）时也不会引起任何行为反应，也不会导致运动障碍，但它在热板试验中确实有短暂的镇痛作用。Spantide II剂量依赖性地减少了由1微克鞘内注射SP诱发的长达30分钟以上的尾部搔抓/咬噬行为，但不阻断鞘内注射生长抑素诱发的尾部搔抓行为。组织学检查显示，用Spantide II治疗后脊髓无病理变化。结果表明，Spantide II是中枢神经系统中一种有效的速激肽拮抗剂，且不会造成神经损伤。