Khalid Sakib K, Crippin Jeffrey S
Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.
Clin Liver Dis. 2006 May;10(2):321-37, ix. doi: 10.1016/j.cld.2006.05.008.
Each year, 5000 to 6000 liver transplantations are performed in the United States, 40% of which are for hepatitis C-related end-stage liver disease. Infection of liver allograft is universal and is associated with an accelerated rate of disease progression. Unfortunately, antiviral therapy after transplantation is less effective and often is beset with complications. This article reviews antiviral therapies and the factors that may influence the response in patients who have HCV infection both immediately before and after liver transplantation.
在美国，每年进行5000至6000例肝移植手术，其中40%是针对丙型肝炎相关终末期肝病。肝移植受者感染普遍存在，且与疾病进展加速相关。不幸的是，移植后的抗病毒治疗效果较差，且常常伴有并发症。本文综述了抗病毒治疗方法以及可能影响肝移植前后感染丙型肝炎病毒患者治疗反应的因素。
