Detection of agents that alter the bacterial cell surface.
作者信息
Jit Sud I, Feingold D S
出版信息
Antimicrob Agents Chemother. 1975 Jul;8(1):34-7. doi: 10.1128/AAC.8.1.34.
Abstract
Proteus mirabilis is not killed by polymyxin B, normal serum, or sodium deoxycholate. Exposure to polymyxin B renders the cells susceptible to killing by the latter two agents. The data suggest that this synergism is due to polymyxin B-induced surface changes. The results point out an inadequacy of existing methods of screening for antibiotics; they fail to detect agents which, while showing no in vitro effect on growth, may alter a resistant organism so that it becomes more susceptible to other antimicrobials or host defense mechanisms. A method is described which can be used to detect such cell surface-modifying agents.
摘要
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