金诺芬抑制大鼠腹膜肥大细胞释放组胺。

Auranofin inhibits histamine release from rat peritoneal mast cells.

作者信息

Shalit M, Levi-Schaffer F

机构信息

Department of Medicine A, Hadassah Medical School, Hebrew University, Jerusalem.

出版信息

Int J Immunopharmacol. 1990;12(4):403-7. doi: 10.1016/0192-0561(90)90022-f.

DOI:10.1016/0192-0561(90)90022-f

PMID:1697286

Abstract

The effect of auranofin on histamine release from immunologic and non-immunologic activated rat peritoneal mast cells cocultured with 3T3 fibroblasts (MC/3T3) was investigated. When MC/3T3 were preincubated with 2 x 10(-5) M auranofin and thereafter challenged with anti-IgE antibodies, a maximal inhibition of histamine release (86.2%) was obtained. Non-immunological histamine release induced by compound 48/80, substance P and bradykinin was inhibited to a lesser degree, i.e. 36.0%, 37.6% and 24.0% respectively. Simultaneous incubation of auranofin and the stimulating agents resulted in a higher inhibition of histamine release: anti-IgE antibodies--92.0%; compound 48/80--73.5%; substance P--46.1%. We conclude that auranofin effectively reduces histamine release from immunologic and non-immunologic activated mast cells. This may be relevant to the control of allergic reactions.

摘要

研究了金诺芬对与3T3成纤维细胞共培养的免疫和非免疫激活大鼠腹膜肥大细胞（MC/3T3）组胺释放的影响。当MC/3T3与2×10⁻⁵ M金诺芬预孵育，然后用抗IgE抗体攻击时，组胺释放得到最大抑制（86.2%）。由化合物48/80、P物质和缓激肽诱导的非免疫性组胺释放受到较小程度的抑制，分别为36.0%、37.6%和24.0%。金诺芬与刺激剂同时孵育导致组胺释放的抑制作用更高：抗IgE抗体——92.0%；化合物48/80——73.5%；P物质——46.1%。我们得出结论，金诺芬可有效减少免疫和非免疫激活肥大细胞的组胺释放。这可能与控制过敏反应有关。