Hachisuka H, Nomura H, Sakamoto F, Mori O, Okubo K, Sasai Y
Department of Dermatology, Kurume University School of Medicine, Japan.
Arch Dermatol Res. 1988;280(3):158-62. doi: 10.1007/BF00456847.
Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine.
已知P物质是肥大细胞的一种强效组胺释放剂。研究了抗组胺药色甘酸二钠（DSCG）、酮替芬和曲尼司特对P物质和化合物48/80诱导的大鼠腹膜肥大细胞组胺释放的影响。这些药物可抑制P物质诱导的组胺释放，而曲尼司特对化合物48/80诱导的组胺释放无抑制作用。我们的研究结果表明，这些抗组胺药可能对可能与P物质和组胺有关的皮肤病有效。
