Leibovitch Igal, Davis Garry, Huilgol Shyamala C, Crompton John, James Craig L, Selva Dinesh
Oculoplastic & Orbital Unit, Department of Ophthalmology & Visual Sciences, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia.
J Cutan Pathol. 2006 Sep;33 Suppl 2:39-41. doi: 10.1111/j.1600-0560.2006.00525.x.
Merkel cell carcinoma (MCC) is an uncommon but potentially aggressive tumor. We describe a rare presentation of MMC of the upper lid.
A 63-year-old male presented with a 3-month history of right upper lid fullness. Examination revealed a large multinodular mass protruding into the conjunctival aspect of the eyelid. An enlarged right submandibular lymph node was also noted.
An incisional biopsy was suggestive of MCC. Staged surgical excision with rapid paraffin sections was performed. The tumor cells were seen invading the tarsal plate and adjacent to the palpebral conjunctiva but not into the epidermis. MCC was confirmed using immunohistochemical stains and neuroendocrine markers (cytokeratins Cam 5.2, AE1/3, CK20, chromogranin, synaptophysin, and Leu 7). The lymph node biopsy was also confirmed as metastatic MCC. The patient was treated with postsurgical chemotherapy and radiotherapy, with no recurrence during a 6 months follow-up period.
Although uncommon, periocular MCC may present as an atypical conjunctival multinodular mass.
默克尔细胞癌（MCC）是一种罕见但具有潜在侵袭性的肿瘤。我们描述了一例上睑MCC的罕见表现。
一名63岁男性，有3个月右上睑饱满的病史。检查发现一个大的多结节肿块突入眼睑结膜面。还注意到右下颌下淋巴结肿大。
切开活检提示为MCC。进行了分期手术切除并快速石蜡切片检查。可见肿瘤细胞侵犯睑板并靠近睑结膜，但未侵犯表皮。使用免疫组织化学染色和神经内分泌标记物（细胞角蛋白Cam 5.2、AE1/3、CK20、嗜铬粒蛋白、突触素和Leu 7）确诊为MCC。淋巴结活检也确诊为转移性MCC。患者接受了术后化疗和放疗，在6个月的随访期内无复发。
尽管罕见，但眼周MCC可能表现为非典型的结膜多结节肿块。
