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糖尿病营中血糖管理措施的安全性与有效性。

Safety and efficacy of blood glucose management practices at a diabetes camp.

作者信息

Gunasekera Hasantha, Ambler Geoffrey

机构信息

Children's Hospital at Westmead, Sydney, New South Wales, Australia.

出版信息

J Paediatr Child Health. 2006 Oct;42(10):643-8. doi: 10.1111/j.1440-1754.2006.00948.x.

Abstract

AIM

Camps are an important part of diabetic management in children yet data on the safety and efficacy of camps are limited. We assessed the safety and efficacy of blood glucose management guidelines at summer camps for diabetic children.

METHODS

Consistent management guidelines were implemented during 10 consecutive diabetes camps held in the same facility between 1998 and 2002. Using the entire sample of campers aged 9-13 years, we analysed insulin dosage alterations, the frequency of hypoglycaemia (<4 mmol/L), hyperglycaemia (>15 mmol/L) and ketosis and evaluated our overnight management guidelines. The effects of sex, year, age, insulin regimen and duration of diagnosis on hypoglycaemia frequency were determined.

RESULTS

Mean insulin doses decreased 19.2% (95% confidence interval 16.9-21.6%) by the last day of camp (day 6) relative to the day prior to camp. Mean blood glucose levels were 11.4 mmol/L before breakfast and the main evening meal, 11.3 mmol/L before bed, 10.8 mmol/L at midnight and 9.4 mmol/L at 3 am. Of the 10 839 readings analysed, 984 (9.1%) were below 4 mmol/L (0.5 per camper/day) with no clinical grade 3 (seizure or coma) hypoglycaemia. Hypoglycaemia frequency was independent of sex, year, age, insulin regimen and duration of diagnosis (all P > 0.05). There were 2570 (23.7%) readings above 15 mmol/L (1.4 per camper/day) but only 42 (0.4%) were associated with significant ketosis.

CONCLUSION

Children at diabetes camps experience considerable blood glucose variability; however, the careful application of monitoring and management guidelines can avoid serious adverse events.

摘要

目的

夏令营是儿童糖尿病管理的重要组成部分,但关于夏令营安全性和有效性的数据有限。我们评估了糖尿病儿童夏令营血糖管理指南的安全性和有效性。

方法

在1998年至2002年期间,于同一设施连续举办的10期糖尿病夏令营中实施了一致的管理指南。我们以9至13岁的全部营员为样本,分析了胰岛素剂量变化、低血糖(<4 mmol/L)、高血糖(>15 mmol/L)和酮症的发生频率,并评估了我们的夜间管理指南。确定了性别、年份、年龄、胰岛素治疗方案和诊断时长对低血糖发生频率的影响。

结果

到夏令营最后一天(第6天),平均胰岛素剂量相对于开营前一天下降了19.2%(95%置信区间为16.9 - 21.6%)。早餐前和晚餐前的平均血糖水平为11.4 mmol/L,睡前为11.3 mmol/L,午夜为10.8 mmol/L,凌晨3点为9.4 mmol/L。在分析的10839次读数中,984次(9.1%)低于4 mmol/L(每位营员每天0.5次),无3级临床低血糖(癫痫或昏迷)。低血糖发生频率与性别、年份、年龄、胰岛素治疗方案和诊断时长无关(所有P>0.05)。有2570次(23.7%)读数高于15 mmol/L(每位营员每天1.4次),但只有42次(0.4%)与明显酮症相关。

结论

糖尿病夏令营中的儿童血糖波动较大;然而,谨慎应用监测和管理指南可避免严重不良事件。

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