Prabhasawat P, Tesavibul N, Kasetsuwan N
Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Br J Ophthalmol. 2007 Jan;91(1):47-50. doi: 10.1136/bjo.2006.097691. Epub 2006 Sep 14.
To assess the short-term efficacy of hypotonic 0.18% sodium hyaluronate in patients with evaporative tear-sufficient dry eye due to lipid tear deficiency (LTD).
This was a randomised, double-blind, controlled, exploratory study. A total of 10 patients with dry eye due to LTD were treated as follows: one drop of hypotonic 0.18% sodium hyaluronate in one eye and one drop of isotonic 0.3% hydroxypropyl-methylcellulose (HPMC)/0.1% dextran in the other eye. Non-invasive tear film break-up time (NIBUT) evaluated by using a tear scope with grid pattern and subjective ocular symptoms of dry eye were assessed at 15, 30, 60 and 90 min after instillation.
Both sodium hyaluronate and HPMC/dextran caused a significant (p<0.05) improvement in NIBUT and symptoms. Mean (SD) NIBUT in the sodium hyaluronate group was 3.2 (1.0), 6.4 (2.8), 5.5 (1.9), 5.3 (1.3) and 3.9 (1.7) s at 0, 15, 30, 60 and 90 min, respectively, compared with 3.6 (1.9), 5.5 (3.2), 5.0 (1.5), 4.4 (2.2) and 3.5 (1.2) s in the HPMC/dextran group. However, increase in NIBUT was significantly (p<0.05) greater and longer in the sodium hyaluronate group than in the HPMC/dextran group.
Treatment with sodium hyaluronate and HPMC/dextran eye drops is useful for treating patients with dry eye due to LTD. However, sodium hyaluronate caused a significantly (p<0.05) greater increase in NIBUT values than HPMC/dextran in such patients.
评估低渗0.18%透明质酸钠对因脂质泪液缺乏（LTD）导致蒸发型泪液充足性干眼患者的短期疗效。
这是一项随机、双盲、对照、探索性研究。总共10例因LTD导致干眼的患者接受如下治疗：一只眼滴入一滴低渗0.18%透明质酸钠，另一只眼滴入一滴等渗0.3%羟丙基甲基纤维素（HPMC）/0.1%右旋糖酐。使用带网格图案的泪液镜评估非侵入性泪膜破裂时间（NIBUT），并在滴入后15、30、60和90分钟评估干眼的主观眼部症状。
透明质酸钠和HPMC/右旋糖酐均使NIBUT和症状有显著（p<0.05）改善。透明质酸钠组在0、15、30、6和90分钟时的平均（标准差）NIBUT分别为3.2（1.0）、6.4（2.8）、5.5（1.9）、5.3（1.3）和3.9（1.7）秒，而HPMC/右旋糖酐组分别为3.6（1.9）、5.5（3.2）、5.0（1.5）、4.4（2.2）和3.5（1.2）秒。然而，透明质酸钠组NIBUT的增加在幅度上显著（p<0.05）大于且持续时间长于HPMC/右旋糖酐组。
使用透明质酸钠和HPMC/右旋糖酐滴眼液治疗因LTD导致干眼的患者是有效的。然而，在此类患者中，透明质酸钠使NIBUT值的增加显著（p<0.05）大于HPMC/右旋糖酐。
