白内障手术后 0.1%和 0.15%透明质酸钠对脂质层和睑板腺的疗效比较：一项随机前瞻性研究。
Comparative efficacy of 0.1% and 0.15% Sodium Hyaluronate on lipid layer and meibomian glands following cataract surgery: A randomized prospective study.
机构信息
Department of Ophthalmology, Pusan National University School of Medicine, Yangsan, South Korea.
Department of Ophthalmology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
出版信息
PLoS One. 2024 Jul 30;19(7):e0306253. doi: 10.1371/journal.pone.0306253. eCollection 2024.
PURPOSE
To compare the efficacy of a 0.15% HA with that of 0.1% HA eye drops for DES after cataract surgery.
METHODS
This study was double blinded, randomized and prospective study, and conducted in 69 participants (70 eyes) from Pusan National University Yangsan Hospital and executed from February 1, 2022 to November 30, 2022. Participants were adult cataract patients with normal lid position, not suffering from any other ocular disease and not meet the exclusion cirteria of clinical trial. Participants were randomly divided into two groups: 35 participants (17 males and 18 females) in the 0.1% HA group and 34 participants (19 males and 15 females) in the 0.15% HA group, receiving treatment six times daily for 6 weeks following cataract surgery. Subjective and objective assessments were performed at preoperative and postoperative visits, including ocular surface disease index score, tear break up time, corneal staining score, Schirmer's I test score, lipid layer thickness), meiboscore, and biochemical analysis of the eye drops.
RESULTS
Throughout the study, the postoperative ocular surface disease index score was significantly lower in the group receiving 0.15% hyaluronic acid than in the group receiving 0.1% hyaluronic acid. Additionally, the postoperative ocular surface disease index score showed a significant positive correlation with the postoperative use of 0.15% hyaluronic acid and the preoperative Schirmer's I test score. In multivariate analysis, treatment with 0.15% hyaluronic acid and the preoperative ocular surface disease index score were significant independent parameters affecting the postoperative ocular surface disease index score.
CONCLUSION
The use of 0.15% hyaluronic acid is recommended for its potential advantages in alleviating symptoms following cataract surgery, making it a viable alternative to traditional 0.1% hyaluronic acid treatment.
TRIAL REGISTRATION
ISRCTN95830348.
目的
比较 0.15%透明质酸（HA）与 0.1%HA 滴眼液对白内障术后 DES 的疗效。
方法
这是一项双盲、随机、前瞻性研究，于 2022 年 2 月 1 日至 11 月 30 日在釜山大学牙山医院进行，共纳入 69 名（70 只眼）成年白内障患者，纳入标准为：眼睑位置正常、无其他眼部疾病、符合临床试验排除标准。将患者随机分为两组：0.1%HA 组 35 名（男 17 名，女 18 名）和 0.15%HA 组 34 名（男 19 名，女 15 名），两组患者在白内障手术后每天接受 6 次治疗，持续 6 周。分别于术前和术后进行主观和客观评估，包括眼表疾病指数（OSDI）评分、泪膜破裂时间（BUT）、角膜染色评分、泪液分泌试验（Schirmer I 试验）、脂质层厚度、睑板腺评分以及眼滴的生化分析。
结果
研究期间，接受 0.15%透明质酸治疗的患者术后 OSDI 评分明显低于接受 0.1%透明质酸治疗的患者。此外，术后 OSDI 评分与术后使用 0.15%透明质酸和术前 Schirmer I 试验评分呈显著正相关。多变量分析显示，使用 0.15%透明质酸和术前眼表疾病指数评分是影响术后眼表疾病指数评分的独立参数。
结论
建议使用 0.15%透明质酸，因为它可能在缓解白内障术后症状方面具有优势，是传统 0.1%透明质酸治疗的一种替代选择。
试验注册号
ISRCTN95830348。
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