Porubský J, Danihel L
Katedry patologickej anatómie LFUK v Bratislave.
Bratisl Lek Listy. 1990 Jun;91(6):484-8.
The expression of some types of cytokeratin and vimentin in the liver was studied by using monoclonal antibodies to these types of intermediary filaments. Necrotic samples from livers without pathological finding were examined. A panel of 5 monoclonal antibodies, prepared in Czechoslovakia, to cytokeratins Nos. 7,8,18, and 19, as well as to vimentin was used. The findings confirmed the characteristic expression of cytokeratins 8 and 18 in hepatocytes and of cytokeratins 7, 8, 18, and 19 in epithelial cells of intrahepatic bile canaliculi, that monoclonal antibodies prepared in Czechoslovakia (LAMO, Brno and VUKEO, Brno) can be successfully used in immunochemical studies of intermediary filaments in the liver.
利用针对这些类型中间丝的单克隆抗体，研究了某些类型细胞角蛋白和波形蛋白在肝脏中的表达。对无病理发现的肝脏坏死样本进行了检查。使用了一组在捷克斯洛伐克制备的针对细胞角蛋白7、8、18和19以及波形蛋白的5种单克隆抗体。研究结果证实了细胞角蛋白8和18在肝细胞中的特征性表达，以及细胞角蛋白7、8、18和19在肝内胆小管上皮细胞中的特征性表达，还证实了在捷克斯洛伐克制备的单克隆抗体（布尔诺的LAMO和布尔诺的VUKEO）可成功用于肝脏中间丝的免疫化学研究。
