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波形蛋白和角蛋白中间丝在K562白血病细胞系中的表达

Vimentin and keratin intermediate filaments expression by K562 leukemic cell line.

作者信息

Zauli D, Gobbi M, Crespi C, Tazzari P L, Miserocchi F, Magnani M, Testoni N

出版信息

Leuk Res. 1986;10(1):29-33. doi: 10.1016/0145-2126(86)90102-5.

DOI:10.1016/0145-2126(86)90102-5
PMID:2418317
Abstract

The expression of intermediate filaments (IMF) by K562 leukemic cell line has been studied by the use of polyclonal and monoclonal antibodies. These cells exhibited an extremely rich network of IMF reacting with both anti-vimentin and anti-keratin antibodies. Although these results need to be confirmed by different techniques, such as immunoblotting, they suggest the possibility that leukemic cell lines can express different types of IMF similarly to other cultured cells.

摘要

利用多克隆抗体和单克隆抗体研究了K562白血病细胞系中间丝(IMF)的表达情况。这些细胞呈现出极其丰富的中间丝网络,能与抗波形蛋白抗体和抗角蛋白抗体发生反应。尽管这些结果需要通过免疫印迹等不同技术加以证实,但它们表明白血病细胞系有可能像其他培养细胞一样表达不同类型的中间丝。

相似文献

1
Vimentin and keratin intermediate filaments expression by K562 leukemic cell line.波形蛋白和角蛋白中间丝在K562白血病细胞系中的表达
Leuk Res. 1986;10(1):29-33. doi: 10.1016/0145-2126(86)90102-5.
2
Microinjection of monoclonal antibodies specific for one intermediate filament protein in cells containing multiple keratins allow insight into the composition of particular 10 nm filaments.在含有多种角蛋白的细胞中显微注射针对一种中间丝蛋白的单克隆抗体,有助于深入了解特定10纳米细丝的组成。
Eur J Cell Biol. 1985 Sep;38(2):234-44.
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[Immunohistochemical analysis of the liver using monoclonal antibodies against intermediate filaments].[使用抗中间丝单克隆抗体对肝脏进行免疫组织化学分析]
Bratisl Lek Listy. 1990 Jun;91(6):484-8.
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[Medullary carcinoma of the breast. Co-expression of keratin intermediate filaments and protein S-100 in tumor cells].
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Subunit structure of desmin and vimentin protofilaments and how they assemble into intermediate filaments.结蛋白和波形蛋白原丝的亚基结构以及它们如何组装成中间丝。
Ann N Y Acad Sci. 1985;455:185-99. doi: 10.1111/j.1749-6632.1985.tb50412.x.
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Modulation of expression of intermediate filaments during the development of established rat liver cell lines.
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An immunocytochemical study of fetal cells at the maternal-placental interface using monoclonal antibodies to keratins, vimentin and desmin.一项使用针对角蛋白、波形蛋白和结蛋白的单克隆抗体对母胎-胎盘界面处胎儿细胞进行的免疫细胞化学研究。
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Placenta. 1988 Sep-Oct;9(5):479-92. doi: 10.1016/0143-4004(88)90020-3.
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Absence of cytokeratin in human hepatoma cell lines.人肝癌细胞系中细胞角蛋白的缺失。
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Expression of intermediate filaments and stromal proteins in granular cell tumor of the tongue.舌颗粒细胞瘤中中间丝及基质蛋白的表达
Oral Surg Oral Med Oral Pathol. 1988 Dec;66(6):689-96. doi: 10.1016/0030-4220(88)90319-2.

引用本文的文献

1
Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines.γ干扰素和粒细胞/巨噬细胞集落刺激因子可抑制小细胞肺癌细胞系的生长并诱导髓系分化特征性抗原的产生。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6613-7. doi: 10.1073/pnas.83.17.6613.
2
Smooth muscle cells can express cytokeratins of "simple" epithelium. Immunocytochemical and biochemical studies in vitro and in vivo.平滑肌细胞可表达“单层”上皮的细胞角蛋白。体内外的免疫细胞化学和生物化学研究。
Am J Pathol. 1988 Aug;132(2):223-32.
3
Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial.
Ber-EP4:一种区分上皮细胞和间皮细胞的新型单克隆抗体。
J Clin Pathol. 1990 Mar;43(3):213-9. doi: 10.1136/jcp.43.3.213.