Brown F
Wellcome Biotech, Beckenham, Kent.
Endeavour. 1990;14(2):87-94. doi: 10.1016/0160-9327(90)90077-5.
Advances made in our knowledge of the structure of foot-and-mouth disease virus have enabled us to identify a fragment, consisting of 20 amino acids, of one of the four proteins of the particle, which elicits neutralizing antibodies in experimental animals and in cattle and pigs. The fragment has been synthesised chemically by Merrifield's solid phase method and biochemically as part of different fusion proteins. The level of the immune response to the peptide, which depends critically on the way it is presented, affords protection against experimental challenge and holds out promise for its future as a vaccine.
我们对口蹄疫病毒结构的认识取得了进展，这使我们能够鉴定出病毒颗粒四种蛋白质之一的一个由20个氨基酸组成的片段，该片段能在实验动物以及牛和猪体内引发中和抗体。该片段已通过梅里菲尔德的固相法进行化学合成，并作为不同融合蛋白的一部分进行生化合成。对该肽的免疫反应水平在很大程度上取决于其呈现方式，它能提供针对实验性攻击的保护，并为其作为疫苗的未来发展带来希望。
