Choi K C, Hashimoto K, Setoyama M, Kagetsu N, Tronnier M, Sturman S
Department of Dermatology and Syphilology, Wayne State University School of Medicine, Detroit, Michigan 48201.
J Cutan Pathol. 1990 Aug;17(4):225-32. doi: 10.1111/j.1600-0560.1990.tb00090.x.
A typical case of infantile digital fibromatosis (IDF) was studied with antibodies raised against actin, vimentin, desmin and several species of cytokeratin. Strong reactions were observed for desmin, cytokeratin and CK-5, and moderate reactions for vimentin and actin. The diagnostic intracytoplasmic inclusion bodies within the tumor cells were ultrastructurally composed of aggregations of dense microfilaments. Immunoelectron microscopy showed that these filament aggregations are positively stained with anti-actin antibody. From these results, we suggest that the large tumor cell of IDF is a myofibroblast and may originate from or differentiate toward vascular smooth muscle cells, because only this type of smooth muscle can coexpress desmin, vimentin and cytokeratin.
我们使用针对肌动蛋白、波形蛋白、结蛋白和几种细胞角蛋白的抗体，对一例典型的婴儿指（趾）纤维瘤病（IDF）进行了研究。观察到结蛋白、细胞角蛋白和CK-5有强反应，波形蛋白和肌动蛋白有中度反应。肿瘤细胞内具有诊断意义的胞质内包涵体在超微结构上由密集微丝聚集而成。免疫电子显微镜显示，这些细丝聚集物被抗肌动蛋白抗体阳性染色。根据这些结果，我们认为IDF的大肿瘤细胞是肌成纤维细胞，可能起源于血管平滑肌细胞或向血管平滑肌细胞分化，因为只有这种类型的平滑肌能够共表达结蛋白、波形蛋白和细胞角蛋白。
