Butler C
Arch Pathol. 1975 Sep;99(9):503-7.
The effects of paraquat in hamsters were evaluated to find a rodent model of interstitial pulmonary disease free from spontaneous infection. Because the repeated doses necessary to produce chronic lung injury suggested hypersensitivity mechanisms, concurrently administered Freund adjuvant and adenocorticotrophic hormone (ACTH) were tested separately. Effects were measured by mortality, change in body weight, and morphometric estimate of lung injury. Findings were as follows: (1) only repeated doses in a very narrow range produced chronic interstitial injury; (2) ACTH clearly protected animals from the general systemic and pulmonary effects of paraquat; and (3) adjuvant specifically protected against the pulmonary injury alone. There was no evidence of immunologic contribution to paraquat injury.
为了找到一种无自发性感染的间质性肺疾病啮齿动物模型，对百草枯在仓鼠身上的作用进行了评估。由于产生慢性肺损伤所需的重复剂量提示存在超敏反应机制，因此分别对同时给予的弗氏佐剂和促肾上腺皮质激素（ACTH）进行了测试。通过死亡率、体重变化和肺损伤的形态学评估来衡量其作用效果。结果如下：（1）仅在非常狭窄的剂量范围内重复给药才会产生慢性间质性损伤；（2）ACTH明显保护动物免受百草枯的全身和肺部总体影响；（3）佐剂仅特异性地保护免受肺部损伤。没有证据表明免疫因素对百草枯损伤有影响。
