Saunier C, Schrijen F, Gille J P, Horsky P, Peslin R, Hartemann D, Foliguet B, Lambert H
Bull Eur Physiopathol Respir. 1982 Nov-Dec;18(6):863-76.
An experimental model of pulmonary interstitial fibrosis was attempted in beagle dogs by intravenous administration of weak doses of paraquat. After various trials, the final protocol involved the intravenous injection of 2 mg/kg repeated every eight days for three weeks, and then every 15 days. On the 70th day, areas of localized interstitial fibrosis were observed (less than 10% of the surface of the tissue sections) in an otherwise healthy parenchyma. There was no marked hepatic or renal lesion. The evolution of the inflammatory and toxic processes was followed by the changes: 1) in the animal's weight (drop in weight after the injection of paraquat), 2) in blood gases (essentially drop in PaO2 and in SaO2), 3) in ventilation and respiratory exchanges (increase of VE and ventilatory frequency, decrease of Duco2), and 4) in static pulmonary compliance (distinct fall after injection). All these modifications showed a close relationship to the pattern of the paraquat injections. They receded 15 days after the last injection and reappeared after a new injection. The pulmonary hemodynamic study carried out only at the beginning of the experiment and before the animal was killed showed only a few anomalies (reduction of the average pressure of the right atrium).
通过静脉注射低剂量百草枯，在比格犬身上尝试建立肺间质纤维化的实验模型。经过多次试验，最终方案为每8天静脉注射2mg/kg，持续3周，然后每15天注射一次。在第70天，在原本健康的实质组织中观察到局部间质纤维化区域（占组织切片表面不到10%）。没有明显的肝或肾损伤。通过以下变化跟踪炎症和毒性过程的演变：1）动物体重（注射百草枯后体重下降），2）血气（主要是PaO2和SaO2下降），3）通气和呼吸交换（VE和通气频率增加，Duco2下降），4）静态肺顺应性（注射后明显下降）。所有这些变化都与百草枯注射模式密切相关。它们在最后一次注射后15天消退，并在新的注射后再次出现。仅在实验开始时和处死动物前进行的肺血流动力学研究仅显示少数异常（右心房平均压力降低）。
