大剂量静脉注射丙种球蛋白治疗新生儿免疫性血小板减少症。
Treatment of neonatal immune thrombocytopenia with high dose intravenous gamma-globulin.
作者信息
Linder N, Shapiro S C, Moser A M, Roitman J, Engelhard D
机构信息
Department of Pediatrics, Hadassah Medical Center, Ein Kerem, Jerusalem, Israel.
出版信息
Dev Pharmacol Ther. 1990;14(4):205-8.
PMID:1697804
Abstract
Five term neonates diagnosed with immune thrombocytopenia were treated with 1 g/kg/day intravenous gamma-globulin. Clinical and laboratory evidence of thrombocytopenia resolved completely in 4 of the 5 patients after a single dose. Only 1 patient received a second dose of the drug. This treatment protocol requires less gamma-globulin than other protocols to safely reduce length of hospitalization.
摘要
五名被诊断为免疫性血小板减少症的足月新生儿接受了每日1克/千克的静脉注射丙种球蛋白治疗。五名患者中有四名在单次给药后血小板减少症的临床和实验室证据完全消失。只有一名患者接受了第二剂药物。与其他治疗方案相比，该治疗方案所需的丙种球蛋白更少，能安全地缩短住院时间。
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