Melbye Hasse, Medbø Astri, Crockett Alan
Institute of Community Medicine, University of Tromsø, 9037 Tromsø, Norway.
Prim Care Respir J. 2006 Oct;15(5):294-8. doi: 10.1016/j.pcrj.2006.07.002. Epub 2006 Sep 15.
To determine the agreement between the FEV1/FEV6 ratio and the FEV1/FVC ratio in an elderly population.
The study sample consisted of 3874 participants in a cross-sectional population survey in Tromsö, Norway, aged 60 years or more, in whom acceptable spirometry had been obtained. Mean differences between the FEV1/FEV6 ratio (%) and the FEV1/FVC ratio (%) were calculated according to age, sex, smoking habit, and the degree of airflow limitation. ROC-curve analysis and Kappa-statistics were used to estimate the utility of the FEV1/FEV6 ratio in predicting an FEV1/FVC ratio < 70%.
The mean difference between FEV1/FEV6% and FEV1/FVC% was 2.7% in both men and women. The difference between the two measures increased somewhat with increasing age, and was more pronounced with smoking and decreasing FEV1/FVC ratio. The value for the FEV1/FEV6 ratio which best predicted an FEV1/FVC ratio of 70%, was 73%, and a very good agreement was found between these two cut-off values (kappa = 0.86).
The FEV1/FEV6 ratio appears to be a good substitute for the FEV1/FVC ratio in an elderly population.
确定老年人群中第一秒用力呼气容积（FEV1）与用力呼气6秒容积（FEV6）之比和FEV1与用力肺活量（FVC）之比之间的一致性。
研究样本包括挪威特罗姆瑟一项横断面人群调查中的3874名年龄在60岁及以上且已获得可接受肺功能测定结果的参与者。根据年龄、性别、吸烟习惯和气流受限程度计算FEV1/FEV6比值（%）和FEV1/FVC比值（%）之间的平均差异。采用ROC曲线分析和Kappa统计量来评估FEV1/FEV6比值在预测FEV1/FVC比值<70%时的效用。
男性和女性的FEV1/FEV6%与FEV1/FVC%之间的平均差异均为2.7%。随着年龄增长，这两种测量方法之间的差异略有增加，在吸烟人群以及FEV1/FVC比值降低时差异更为明显。最能预测FEV1/FVC比值为70%的FEV1/FEV6比值为73%，这两个临界值之间存在非常好的一致性（kappa = 0.86）。
在老年人群中，FEV1/FEV6比值似乎是FEV1/FVC比值的良好替代指标。
