诺氯前列素、尼罗前列素、伊洛前列素及（15S）-15-甲基前列腺素E2对应激、吲哚美辛和乙醇所致胃黏膜损伤的影响。

The effects of nocloprost, nileprost, iloprost and (15 S)-15-methyl-PGE2 on gastric mucosal damage induced by stress, indomethacin and ethanol.

作者信息

Zengil H, Ercan Z S, Onuk E, Turker R K

机构信息

Department of Pharmacology, Faculty of Medicine, Gazi University, Turkey.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):13-6. doi: 10.1016/0952-3278(90)90109-x.

DOI:10.1016/0952-3278(90)90109-x

PMID:1697972

Abstract

The preventive effects of nocloprost, nileprost, iloprost and (15S)-15-Methyl-prostaglandin E2 were studied in the rat gastric mucosal damage induced by restraint-cold stress, indomethacin and ethanol. Nocloprost was found to be the most potent orally active compound against rat mucosal damage induced by all noxious stimuli used in this study. Both nocloprost and iloprost were more effective on stress-induced ulcers than on those induced by indomethacin and ethanol. Nocloprost and 15-methyl prostaglandin E2 were also more active on ethanol-induced mucosal damage than on induced by indomethacin. No significant differences were obtained with iloprost and nileprost on indomethacin and ethanol-induced mucosal injury. These results indicate a more potent oral antiulcer activity of nocloprost.

摘要

研究了诺克洛前列素、尼罗前列素、伊洛前列素和（15S）-15-甲基前列腺素E2对束缚-冷应激、吲哚美辛和乙醇诱导的大鼠胃黏膜损伤的预防作用。结果发现，诺克洛前列素是本研究中对所有有害刺激诱导的大鼠黏膜损伤最有效的口服活性化合物。诺克洛前列素和伊洛前列素对应激性溃疡的疗效比对吲哚美辛和乙醇诱导的溃疡更有效。诺克洛前列素和15-甲基前列腺素E2对乙醇诱导的黏膜损伤也比对吲哚美辛诱导的更具活性。伊洛前列素和尼罗前列素对吲哚美辛和乙醇诱导的黏膜损伤无显著差异。这些结果表明诺克洛前列素具有更强的口服抗溃疡活性。