Zengil H, Onuk E, Ercan Z S, Türker R K
Department of Pharmacology, Faculty of Medicine, Gazi University, Turkey.
Prostaglandins Leukot Med. 1987 Dec;30(2-3):61-7. doi: 10.1016/0262-1746(87)90135-1.
This study was undertaken to evaluate the efficacy of iloprost and UK 38485 in the prevention of gastric lesions due to restraint-cold stress, ethanol or indomethacin. Prior injection of iloprost to the rats significantly prevented the increase in ulcer index by restraint- cold stress or indomethacin but nonsignificantly reduced the ulcer index induced by ethanol. UK 38 485 at lower doses caused a highly significant decrease in the ulcer index induced by all noxious stimuli used in this study. UK 38 485 also reduced the increased 3H back diffusion due to restraint-cold stress. Higher doses of the compound, however, failed to decrease the mucosal damage due to restraint-cold stress. Combination of iloprost and UK 38 485 produced a further significant decrease in the ulcer index induced by all noxious stimuli and increased 3H back diffusion induced by restraint-cold stress. In relation to these results the importance of PGI2/TXA2 ratio in the production of gastric mucosal lesions is discussed.
本研究旨在评估伊洛前列素和UK 38485在预防因束缚-冷应激、乙醇或吲哚美辛所致胃损伤方面的疗效。预先给大鼠注射伊洛前列素可显著预防束缚-冷应激或吲哚美辛所致溃疡指数的升高，但对乙醇诱导的溃疡指数降低不显著。较低剂量的UK 38485可使本研究中所用的所有有害刺激诱导的溃疡指数显著降低。UK 38485还可减少因束缚-冷应激导致的3H反向扩散增加。然而，该化合物的较高剂量未能减轻因束缚-冷应激所致的黏膜损伤。伊洛前列素与UK 38485联合使用可使所有有害刺激诱导的溃疡指数进一步显著降低，并使束缚-冷应激诱导的3H反向扩散增加。针对这些结果，讨论了PGI2/TXA2比值在胃黏膜损伤发生中的重要性。
