Hunt R D, Barahona H H, King N W, Fraser C E, Garcia F G, Meléndez L V
Bibl Haematol. 1975(40):351-5. doi: 10.1159/000397552.
Three examples of spontaneous malignant lymphoma were observed in owl monkeys 23, 81, and 183 days after arrival in our laboratories. The pathological features of the disease were analogous to experimentally induced Herpesvirus saimiri lymphoma. H. saimiri was recovered from 2 animals (it was not attempted from one case) and one isolate was shown to reproduce characteristic H. saimiri malignant lymphoma. Each monkey originated in Peru in contrast to our usual source of owl monkeys which originate in Barranquilla, Colombia. Samples collected from owl monkeys in Peru did not reveal antibodies to H. saimiri nor were virus isolated from cocultured leukocytes. Squirrel monkeys in the same geographical location all carried H. saimiri. The observations indicate that H. saimiri lymphoma can occur as a spontaneous disease and that the virus can cross the same taxonomic lines in nature as in the laboratory.
在抵达我们实验室23天、81天和183天后，在夜猴中观察到三例自发性恶性淋巴瘤。该疾病的病理特征类似于实验诱导的赛氏疱疹病毒淋巴瘤。从2只动物中分离出了赛氏疱疹病毒（未对其中1例进行尝试），并且有1株分离株显示可引发典型的赛氏疱疹病毒恶性淋巴瘤。与我们通常获取的原产于哥伦比亚巴兰基亚的夜猴不同，每只猴子都原产于秘鲁。从秘鲁的夜猴身上采集的样本未检测到赛氏疱疹病毒抗体，从共培养的白细胞中也未分离出病毒。同一地理位置的松鼠猴均携带赛氏疱疹病毒。这些观察结果表明，赛氏疱疹病毒淋巴瘤可作为一种自发性疾病发生，并且该病毒在自然界中能够像在实验室中一样跨越相同的分类界限。
