结节病的抗真菌治疗——一项初步干预试验。
Antifungal treatment in sarcoidosis--a pilot intervention trial.
作者信息
Tercelj Marjeta, Rott Tomaz, Rylander Ragnar
机构信息
Unit of Respiratory Diseases and Allergy, University Medical Center, Clinical Center, Zaloska 7, 1525 Ljubljana, Slovenia.
出版信息
Respir Med. 2007 Apr;101(4):774-8. doi: 10.1016/j.rmed.2006.08.005. Epub 2006 Sep 18.
BACKGROUND
Sarcoidosis is generally treated with corticosteroids that are not always an effective therapy.
OBJECTIVES
To assess if treatment with antifungal drugs would improve the clinical status of patients with sarcoidosis.
METHODS
Patients (n=18) with sarcoidosis grades II and III according to established criteria and without clinical and immunological signs of fungal infection, were treated with antifungal medication together with corticosteroids for 3-6 months. Pulmonary X-ray infiltration, lung function, and severity of symptoms were registered before and after the treatment and at follow up 9-58 months later.
RESULTS
The treatment resulted in statistically significant decreases in the degree of pulmonary infiltration with an average decrease in the group from 2.0 to 1.0. There were also significant increases in diffusion capacity and decreases in the severity of symptoms.
CONCLUSION
It is suggested that treatment with antifungal drugs may be useful, at least in certain cases of sarcoidosis.
背景
结节病通常采用皮质类固醇进行治疗，但这种治疗方法并非总是有效。
目的
评估抗真菌药物治疗是否能改善结节病患者的临床状况。
方法
根据既定标准，选取18例II级和III级结节病患者，这些患者无真菌感染的临床和免疫学迹象，采用抗真菌药物联合皮质类固醇治疗3至6个月。在治疗前后以及9至58个月后的随访中记录肺部X线浸润、肺功能和症状严重程度。
结果
治疗后肺部浸润程度在统计学上有显著降低，该组平均从2.0降至1.0。弥散能力也有显著提高，症状严重程度降低。
结论
提示抗真菌药物治疗可能有用，至少在某些结节病病例中如此。
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