Kiebler Michael A, Bassell Gary J
Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria.
Neuron. 2006 Sep 21;51(6):685-90. doi: 10.1016/j.neuron.2006.08.021.
RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought. Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than previously anticipated. We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation.
RNA定位有助于细胞极性和突触可塑性。将讨论相关证据，即神经元中的RNA运输和局部翻译可能比最初认为的联系更为紧密。其次，神经元RNA颗粒最初被定义为参与mRNA运输的中间体，但其组成和功能比先前预期的要多样化得多。我们聚焦于三类RNA颗粒，包括运输核糖核蛋白、应激颗粒和P小体，并讨论它们在RNA定位、微小RNA介导的翻译调控和mRNA降解中的潜在功能。
