Romero R, Jimenez C, Lohda A K, Nores J, Hanaoka S, Avila C, Callahan R, Mazor M, Hobbins J C, Diamond M P
Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06510.
Am J Obstet Gynecol. 1990 Sep;163(3):968-74. doi: 10.1016/0002-9378(90)91106-m.
The purpose of this study was to determine whether amniotic fluid glucose concentrations is of value in the rapid diagnosis of intraamniotic infection. Amniocenteses were performed in 168 patients with preterm labor and intact membranes. Amniotic fluid was cultured for aerobic and anaerobic bacteria, as well as Mycoplasma species. The prevalence of positive amniotic fluid cultures was 13.6% (23/168). Patients with positive amniotic fluid cultures for microorganisms had significantly lower median amniotic fluid glucose concentrations than patients with negative amniotic fluid cultures (median 11 mg/dl, range 2 to 30 mg/dl vs median 28 mg/dl, range 3 to 74, respectively; p less than 0.001). Amniotic fluid glucose concentrations below 14 mg/dl had a sensitivity of 86.9% (20/23), a specificity of 91.7% (133/145), a positive predictive value of 62.5% (20/32), and a negative predictive value of 97.8% (133/136) in the detection of a positive amniotic fluid culture. Amniotic fluid glucose determination is a rapid, sensitive, inexpensive, and simple test for the detection of intraamniotic infection in women with preterm labor and intact membranes.
本研究的目的是确定羊水葡萄糖浓度在羊膜腔内感染快速诊断中是否具有价值。对168例胎膜完整的早产患者进行了羊膜腔穿刺。对羊水进行需氧菌、厌氧菌以及支原体培养。羊水培养阳性率为13.6%（23/168）。羊水微生物培养阳性的患者，其羊水葡萄糖浓度中位数显著低于羊水培养阴性的患者（分别为中位数11mg/dl，范围2至30mg/dl与中位数28mg/dl，范围3至74；p<0.001）。在检测羊水培养阳性方面，羊水葡萄糖浓度低于14mg/dl时，敏感性为86.9%（20/23），特异性为91.7%（133/145），阳性预测值为62.5%（20/32），阴性预测值为97.8%（133/136）。羊水葡萄糖测定是一种用于检测胎膜完整的早产女性羊膜腔内感染的快速、敏感、廉价且简单的检测方法。
