Ito Yasuhiro, Jikuzono Tomoo, Higashiyama Takuya, Asahi Shuji, Tomoda Chisato, Takamura Yuuki, Miya Akihiro, Kobayashi Kaoru, Matsuzuka Fumio, Kuma Kanji, Miyauchi Akira
Kuma Hospital, 8-2-35, Shimoyamate-Dori, Chuo-ku, Kobe City, 650-0011, Japan.
World J Surg. 2006 Oct;30(10):1821-8. doi: 10.1007/s00268-006-0211-5.
Previous studies have shown that lymph node metastasis can be of prognostic value. In this study, we investigated the clinical significance of node metastasis focusing on metastasis in the central compartment for patients with papillary carcinoma located in one lobe.
We investigated the frequency of lymph node metastasis in 759 patients with papillary carcinoma to determine whether and how such metastasis affects disease-free survival (DFS).
Central node metastasis was observed in 63% of patients, and the frequency was increased in relation to tumor size. The frequency of lateral node metastasis was 62.0%, which was also directly related to tumor size. On multivariate analysis of cases showing tumor larger than 1 cm, central node metastasis was recognized as an independent prognostic factor of DFS. The frequency of metastasis to the paratracheal nodes contralateral to the tumor was drastically elevated for tumors larger than 1 cm, but metastasis to this region did not independently predict worse DFS.
Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm.
既往研究表明，淋巴结转移具有预后价值。在本研究中，我们聚焦于单叶乳头状癌患者中央区的转移情况，探讨淋巴结转移的临床意义。
我们调查了759例乳头状癌患者的淋巴结转移频率，以确定这种转移是否以及如何影响无病生存期（DFS）。
63%的患者出现中央区淋巴结转移，且转移频率随肿瘤大小增加而升高。侧方淋巴结转移频率为62.0%，同样与肿瘤大小直接相关。在对肿瘤大于1 cm的病例进行多因素分析时，中央区淋巴结转移被认为是DFS的独立预后因素。对于大于1 cm的肿瘤，肿瘤对侧气管旁淋巴结的转移频率显著升高，但该区域的转移并不能独立预测更差的DFS。
中央区淋巴结转移可独立预测肿瘤大于1 cm的乳头状癌患者DFS更差。
