Barron K S, Montalvo J F, Joseph A K, Hilario M O, Saadeh C, Giannini E H, Orson F M
Texas Children's Hospital, Houston 77030.
Arthritis Rheum. 1990 Sep;33(9):1371-7. doi: 10.1002/art.1780330909.
We studied levels of soluble interleukin-2 receptors (IL-2R) in serial serum samples obtained from 93 patients with Kawasaki syndrome, using a double-antibody "sandwich" enzyme-linked immunosorbent assay technique. Concentrations of soluble IL-2R were significantly increased in Kawasaki syndrome patients in the first 4 weeks of illness when compared with either healthy adult or pediatric controls (P less than 0.02), and in the first 2 weeks of illness when compared with a group of children with measles (P less than 0.0001). Furthermore, in the second week of illness, levels of soluble IL-2R were significantly greater in children who subsequently developed coronary artery aneurysms than in patients with normal appearing coronary arteries. Serum concentration of soluble IL-2R is a useful marker for detecting early Kawasaki syndrome and identifies those patients who are at greater risk of developing coronary artery aneurysms.
我们采用双抗体“夹心”酶联免疫吸附测定技术，研究了93例川崎病患者系列血清样本中可溶性白细胞介素-2受体（IL-2R）的水平。与健康成人或儿童对照组相比，川崎病患者在发病的前4周可溶性IL-2R浓度显著升高（P<0.02），与一组麻疹患儿相比，在发病的前2周可溶性IL-2R浓度显著升高（P<0.0001）。此外，在发病的第二周，随后发生冠状动脉瘤的儿童的可溶性IL-2R水平显著高于冠状动脉外观正常的患者。可溶性IL-2R的血清浓度是检测早期川崎病的有用标志物，并可识别那些发生冠状动脉瘤风险更高的患者。
