Tack J, Coulie B, Verbeke K, Janssens J
Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium.
Aliment Pharmacol Ther. 2006 Oct 1;24(7):1045-50. doi: 10.1111/j.1365-2036.2006.03095.x.
Although delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated.
To investigate the influence of delaying gastric emptying rate in healthy volunteers on the occurrence of meal-related symptoms.
Fourteen healthy subjects (six men, mean age 23 +/- 1) underwent gastric emptying studies twice using the 14C octanoic acid and 13C glycin breath test after pre-treatment with saline or sumatriptan 6 mg s.c. Breath samples were taken before meal and at 15-min intervals for a period of 360 min postprandially. At each breath sampling, the subject was asked to grade the intensity (0-6) of four dyspeptic symptoms.
Sumatriptan pre-treatment significantly delayed solid but not liquid gastric emptying (t1/2 respectively 159 +/- 11 vs. 112 +/- 9 min, P < 0.005 and 134 +/- 11 vs. 116 +/- 12 min, N.S.). Sumatriptan significantly decreased the mean cumulative symptom score (21.3 +/- 5.5 vs. 8.0 +/- 2.6, P = 0.01), as well as scores for each individual symptom.
A moderate delay in gastric emptying in health is not associated with an increase of meal-related symptoms. This observation argues against a causal role for delayed gastric emptying in the pathogenesis of dyspeptic symptoms.
尽管在功能性消化不良中经常发现胃排空延迟，但尚未证实排空延迟在诱发症状方面的因果作用。
研究健康志愿者胃排空率延迟对进餐相关症状发生的影响。
14名健康受试者（6名男性，平均年龄23±1岁）在接受生理盐水或皮下注射6mg舒马曲坦预处理后，使用14C辛酸和13C甘氨酸呼气试验进行两次胃排空研究。餐前及餐后360分钟内每隔15分钟采集呼气样本。在每次呼气采样时，要求受试者对四种消化不良症状的强度（0-6级）进行评分。
舒马曲坦预处理显著延迟了固体而非液体的胃排空（t1/2分别为159±11分钟对112±9分钟，P<0.005；134±11分钟对116±12分钟，无统计学意义）。舒马曲坦显著降低了平均累积症状评分（21.3±5.5对8.0±2.6，P=0.01），以及每种个体症状的评分。
健康人胃排空适度延迟与进餐相关症状增加无关。这一观察结果反对胃排空延迟在消化不良症状发病机制中的因果作用。
