Gastroenterology Division, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
World J Gastroenterol. 2012 Jul 14;18(26):3415-9. doi: 10.3748/wjg.v18.i26.3415.
To determine the effect of oral sumatriptan on gastric emptying using a continuous ¹³C breath test (BreathID system).
Ten healthy male volunteers participated in this randomized, 2-way crossover study. The subjects fasted overnight and were randomly assigned to receive a test meal (200 kcal/200 mL) 30 min after pre-medication with sumatriptan 50 mg (sumatriptan condition), or the test meal alone (control condition). Gastric emptying was monitored for 4 h after administration of the test meal by the ¹³C-acetic acid breath test performed continually using the BreathID system. Then, using Oridion Research Software (β version), the time taken for emptying of 50% of the labeled meal (T(1/2)) similar to the scintigraphy lag time for 10% emptying of the labeled meal (T(lag)), the gastric emptying coefficient (GEC), and the regression-estimated constants (β and κ) were calculated. The statistical significance of any differences in the parameters were analyzed using Wilcoxon's signed-rank test.
In the sumatriptan condition, significant differences compared with the control condition were found in T(1/2) [median 131.84 min (range, 103.13-168.70) vs 120.27 min (89.61-138.25); P = 0.0016], T(lag) [median 80.085 min (59.23-125.89) vs 61.11 min (39.86-87.05); P = 0.0125], and β [median 2.3374 (1.6407-3.8209) vs 2.0847 (1.4755-2.9269); P = 0.0284]. There were no significant differences in the GEC or κ between the 2 conditions.
This study showed that oral sumatriptan significantly delayed gastric emptying of a liquid meal.
使用连续 ¹³C 呼气试验（BreathID 系统）确定口服舒马曲坦对胃排空的影响。
10 名健康男性志愿者参与了这项随机、双交叉研究。受试者禁食过夜，随机分为舒马曲坦 50mg 预处理后 30 分钟接受试验餐（200 千卡/200 毫升）（舒马曲坦组），或单独接受试验餐（对照组）。给药后 4 小时通过 BreathID 系统连续进行 ¹³C-乙酸呼气试验监测胃排空。然后，使用 Oridion Research Software（β 版）计算排空标记餐的 50%（T(1/2)）相似的闪烁扫描法排空 10%标记餐的滞后时间（T(lag)）、胃排空系数（GEC）和回归估计常数（β和κ）。使用 Wilcoxon 符号秩检验分析参数差异的统计学意义。
与对照组相比，舒马曲坦组 T(1/2) [中位数 131.84 分钟（范围，103.13-168.70）比 120.27 分钟（89.61-138.25）；P = 0.0016]、T(lag) [中位数 80.085 分钟（59.23-125.89）比 61.11 分钟（39.86-87.05）；P = 0.0125] 和β[中位数 2.3374（1.6407-3.8209）比 2.0847（1.4755-2.9269）；P = 0.0284] 差异有统计学意义。两组间 GEC 或 κ 无显著差异。
本研究表明，口服舒马曲坦可显著延迟液体餐的胃排空。
