Begum Mosammat R, Quadir Ehsan, Begum Anowara, Begum Rowsan A, Begum Momtaz
Dhaka Medical College and Hospital, Dhaka, Bangladesh.
J Obstet Gynaecol Res. 2006 Oct;32(5):502-6. doi: 10.1111/j.1447-0756.2006.00434.x.
To examine the efficacy of aromatase inhibitor in the induction of ovulation.
This prospective clinical trial in patients with infertility and poor response to clomiphene citrate (CC) was undertaken in a tertiary referral infertility clinic. Thirty-five infertile patients, who were treated by clomiphene citrate for several cycles and referred to the infertility clinic, were the target population. Initially, the response of CC was assessed by same dose of CC that the patient had in her last cycle. The patients who did not respond adequately were treated by aromatase inhibitor 2.5-5 mg/day from day 3-7 of the menstrual cycle. The main outcome measures were the number of mature follicles, ovulation rate, endometrial thickness and pregnancy rate.
Twenty-seven (90%) patients developed mature follicles by day 12. The majority (77.77%) developed single follicle. Except for one cycle of one patient, the follicles of all patients were ruptured in all cycles and seven (25.94%) got pregnant.
The aromatase inhibitor letrozole is effective for ovulation induction in anovulatory infertility in patients that failed to ovulate by CC.
探讨芳香化酶抑制剂诱导排卵的疗效。
这项针对不孕且对枸橼酸氯米芬（CC）反应不佳患者的前瞻性临床试验在一家三级转诊不孕诊所进行。目标人群为35名接受过多个周期枸橼酸氯米芬治疗后转诊至不孕诊所的不孕患者。最初，通过患者上一周期相同剂量的CC评估其对CC的反应。对反应不充分的患者在月经周期第3 - 7天给予2.5 - 5毫克/天的芳香化酶抑制剂治疗。主要观察指标为成熟卵泡数量、排卵率、子宫内膜厚度和妊娠率。
27名（90%）患者在第12天时发育出成熟卵泡。大多数（77.77%）发育出单个卵泡。除一名患者的一个周期外，所有患者的卵泡在所有周期均破裂，7名（25.94%）患者怀孕。
芳香化酶抑制剂来曲唑对CC治疗无效的无排卵性不孕症患者诱导排卵有效。
