Topipat Chutima, Choktanasiri Wicharn, Jultanmas Rattiya, Weerakiet Sawaek, Wongkularb Anna, Rojanasakul Aram
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Gynecol Endocrinol. 2008 Mar;24(3):145-50. doi: 10.1080/09513590801895609.
To compare the effect of the aromatase inhibitor letrozole and clomiphene citrate (CC) on superovulation in women with normal ovulation.
A cross-over randomized study of 22 women with normal ovulation, divided randomly into two equal cohorts, was carried out. Each group of 11 women was randomly allocated to take letrozole or CC for one cycle. After washing out for one cycle, the alternative drug was administered in the subsequent cycle. The number and size of mature follicles, endometrial thickness, and estradiol and progesterone levels were monitored.
The number of mature follicles and estradiol levels on ovulation day were significantly lower in the letrozole group than the CC group (p < 0.05 for both). However, no differences between the two groups in endometrial thickness and pattern were observed. Progesterone levels showed ovulation in all cycles.
The administration of 50 mg CC on days 3-5 was superior to 2.5 mg letrozole for superovulation induction in women with normal ovulation.
比较芳香化酶抑制剂来曲唑与枸橼酸氯米芬（CC）对排卵正常女性超排卵的影响。
对22名排卵正常的女性进行交叉随机研究，随机分为两个相等的队列。每组11名女性随机分配服用来曲唑或CC一个周期。经过一个周期的洗脱期后，在随后的周期中给予另一种药物。监测成熟卵泡的数量和大小、子宫内膜厚度以及雌二醇和孕酮水平。
来曲唑组排卵日成熟卵泡数量和雌二醇水平显著低于CC组（两者均p < 0.05）。然而，两组在子宫内膜厚度和形态方面未观察到差异。所有周期的孕酮水平均显示有排卵。
对于排卵正常的女性，在第3 - 5天服用50 mg CC诱导超排卵优于2.5 mg来曲唑。
