Ombelet Willem, Cooke Ian, Dyer Silke, Serour Gamal, Devroey Paul
Department of Obstetrics and Gynaecology, Genk Institute for Fertility Technology, Schiepse Bos 6, 3600 Genk, Belgium.
Hum Reprod Update. 2008 Nov-Dec;14(6):605-21. doi: 10.1093/humupd/dmn042. Epub 2008 Sep 26.
Worldwide more than 70 million couples suffer from infertility, the majority being residents of developing countries. Negative consequences of childlessness are experienced to a greater degree in developing countries when compared with Western societies. Bilateral tubal occlusion due to sexually transmitted diseases and pregnancy-related infections is the most common cause of infertility in developing countries, a condition that is potentially treatable with assisted reproductive technologies (ART). New reproductive technologies are either unavailable or very costly in developing countries. This review provides a comprehensive survey of all important papers on the issue of infertility in developing countries.
Medline, PubMed, Excerpta Medica and EMBASE searches identified relevant papers published between 1978 and 2007 and the keywords used were the combinations of 'affordable, assisted reproduction, ART, developing countries, health services, infertility, IVF, simplified methods, traditional health care'.
The exact prevalence of infertility in developing countries is unknown due to a lack of registration and well-performed studies. On the other hand, the implementation of appropriate infertility treatment is currently not a main goal for most international non-profit organizations. Keystones in the successful implementation of infertility care in low-resource settings include simplification of diagnostic and ART procedures, minimizing the complication rate of interventions, providing training-courses for health-care workers and incorporating infertility treatment into sexual and reproductive health-care programmes.
Although recognizing the importance of education and prevention, we believe that for the reasons of social justice, infertility treatment in developing countries requires greater attention at National and International levels.
全球有超过7000万对夫妇患有不孕症,其中大多数是发展中国家的居民。与西方社会相比,发展中国家无子女所带来的负面影响更为严重。性传播疾病和与妊娠相关的感染导致的双侧输卵管阻塞是发展中国家不孕症最常见的原因,这种情况可通过辅助生殖技术(ART)进行潜在治疗。在发展中国家,新的生殖技术要么无法获得,要么成本非常高昂。本综述全面调查了所有关于发展中国家不孕症问题的重要论文。
通过检索Medline、PubMed、医学文摘数据库(Excerpta Medica)和EMBASE,确定了1978年至2007年间发表的相关论文,使用的关键词组合为“可负担的、辅助生殖、ART、发展中国家、卫生服务、不孕症、体外受精、简化方法、传统医疗保健”。
由于缺乏登记和完善的研究,发展中国家不孕症的确切患病率尚不清楚。另一方面,目前实施适当的不孕症治疗并非大多数国际非营利组织的主要目标。在资源匮乏地区成功实施不孕症护理的关键包括简化诊断和ART程序、将干预的并发症发生率降至最低、为医护人员提供培训课程以及将不孕症治疗纳入性与生殖健康护理计划。
尽管认识到教育和预防的重要性,但我们认为,出于社会正义的原因,发展中国家的不孕症治疗在国家和国际层面需要得到更多关注。