Sutherland John C
Physics Department, East Carolina University, Greenville, NC 27858, USA.
Phys Med Biol. 2006 Oct 7;51(19):4883-901. doi: 10.1088/0031-9155/51/19/011. Epub 2006 Sep 14.
The probability of survival of cells or viruses exposed to various forms of radiation is expressed as a function of the probability that a given cell will receive a certain number of lethal damages, the average probability that each such damage is repairable, and an upper bound on the repair capacity of each cell. All lethal damages are presumed induced as a linear function of dose. The probability of survival is found to be the product of a single exponential, which reflects inactivation by unrepairable lethal damages and dominates at low doses, and an Euler gamma function, which reflects inactivation due to repairable damages formed in excess of the upper bound on repair capacity. Computational procedures obtain stochastic parameters from published survival data for the inactivation of bacterial, yeast and mammalian cells exposed to ionizing or ultraviolet radiation, including split-dose experiments. The survival of cells exposed to photodynamic therapy is analysed assuming that lethal damages cannot be repaired, but more than one may be required for inactivation.
暴露于各种形式辐射下的细胞或病毒的存活概率，表示为给定细胞接受一定数量致死性损伤的概率、每个此类损伤可修复的平均概率以及每个细胞修复能力上限的函数。假定所有致死性损伤都是剂量的线性函数。发现存活概率是一个单指数的乘积，该单指数反映了不可修复的致死性损伤导致的失活，且在低剂量时占主导，以及一个欧拉伽马函数，该函数反映了由于形成的可修复损伤超过修复能力上限而导致的失活。计算程序从已发表的关于暴露于电离或紫外线辐射下的细菌、酵母和哺乳动物细胞失活的存活数据中获取随机参数，包括分次剂量实验。假设致死性损伤无法修复，但失活可能需要不止一个损伤，对暴露于光动力疗法下的细胞存活情况进行了分析。
