针对大鼠肝癌D23腹水变异株的血清抗体反应。
Serum antibody responses to an ascitic variant of rat hepatoma D23.
作者信息
Robins R A
出版信息
Br J Cancer. 1975 Jul;32(1):21-7. doi: 10.1038/bjc.1975.129.
Antibody was detected by membrane immunofluorescence tests in sera of rats bearing an ascitic variant of a transplanted hepatoma, and in concentrated cell-free ascitic fluid. Ascites hepatoma cells were also shown to have immunoglobulin, possibly tumour specific antibody, bound to their surface. The kinetics of antibody responses to ascites hepatoma and hepatoma cells from solid tumours were compared: both tumour types gave positive reactions by the third day after implantation; antibody was present throughout subsequent tumour growth with the ascites whereas antibody was not detected after tumour became palpable in rats injected with hepatoma cells from solid tumour. Antibody responses to ascites tumour were investigated in rats bearing solid hepatoma tumour. Subcutaneous hepatoma did not influence the antibody response to ascites, but rats bearing intraperitoneal tumours showed a diminished serum antibody response to ascitic hepatoma.
通过膜免疫荧光试验在携带移植性肝癌腹水变异型的大鼠血清以及浓缩的无细胞腹水中检测到了抗体。腹水肝癌细胞表面也显示有免疫球蛋白，可能是肿瘤特异性抗体。比较了对腹水肝癌和实体瘤肝癌细胞抗体反应的动力学：两种肿瘤类型在植入后第三天均产生阳性反应；在随后腹水肿瘤生长的整个过程中均存在抗体，而在注射实体瘤肝癌细胞的大鼠中，肿瘤可触及后未检测到抗体。对携带实体肝癌肿瘤的大鼠腹水肿瘤的抗体反应进行了研究。皮下肝癌不影响对腹水的抗体反应，但携带腹腔内肿瘤的大鼠对腹水肝癌的血清抗体反应减弱。
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