卡介苗对大鼠恶性胸腔积液的治疗作用
BCG treatment of malignant pleural effusions in the rat.
作者信息
Pimm M V, Hopper D G, Baldwin R W
出版信息
Br J Cancer. 1976 Oct;34(4):368-73. doi: 10.1038/bjc.1976.179.
Abstract
Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour injection. In contrast, active specific immunotherapy by repeated s.c. injection of viable or radiation-attenuated tumour cells in admixture with BCG was unsuccessful, and did not improve the response to intrapleural BCG treatment.
摘要
向大鼠胸腔内注射腹水瘤细胞可导致胸腔积液和胸膜实性沉积物。将卡介苗（BCG）或其甲醇提取残渣（MER）注入胸腔可抑制肿瘤发展并延长生存期。在肿瘤注射前或后数天给予治疗均有效。相比之下，通过反复皮下注射活的或经辐射减毒的肿瘤细胞与BCG混合进行主动特异性免疫治疗未获成功，也未改善胸腔内BCG治疗的效果。
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