Trost Barry M, Weiss Andrew H
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Org Lett. 2006 Sep 28;8(20):4461-4. doi: 10.1021/ol0615836.
A catalytic enantioselective total synthesis of adociacetylene B (2) in five steps is reported. The efficiency of this synthesis was enabled by an asymmetric zinc alkynylation catalyzed by the proline-derived ligand (1).
报道了通过五步催化对映选择性全合成阿多西乙炔B（2）。该合成的效率得益于脯氨酸衍生配体（1）催化的不对称锌炔基化反应。
