与氮原子相邻的前手性sp3 C-H键的催化对映选择性炔基化反应。
Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom.
作者信息
Li Zhiping, Li Chao-Jun
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
Org Lett. 2004 Dec 23;6(26):4997-9. doi: 10.1021/ol047814v.
PMID:15606119
Abstract
[reaction: see text] The construction of chiral carbon centers via the first catalytic asymmetric alkynylation of prochiral CH2 groups was developed by using a copper-catalyzed double activation of sp3 and sp C-H bonds. Optically active 1-alkynylated tetrahydroisoquinolines were obtained by this method.
摘要
[反应：见正文] 通过使用铜催化的sp3和sp C-H键的双重活化，开发了一种通过前手性CH2基团的首次催化不对称炔基化构建手性碳中心的方法。通过该方法获得了光学活性的1-炔基化四氢异喹啉。
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