Kröll-Seger Judith, Mothersill Ian William, Novak Simon, Sälke-Kellermann Ritva Anneli, Krämer Günter
Paediatric Department, Swiss Epilepsy Centre, Zurich, Switzerland.
Epileptic Disord. 2006 Sep;8(3):213-8.
We report on a 3-year-old boy with myoclonic-astatic epilepsy who developed myoclonic status epilepticus with continuous twitching of the face and unresponsiveness under monotherapy with levetiracetam. Recently, a nonconvulsive status epilepticus in an adult epilepsy patient has also been described. Our observation points to the possibility of a causal relationship between the induction of myoclonic status by levetiracetam in certain patients with Doose's syndrome. However, a spontaneous evolution cannot be excluded. Levetiracetam is a well-known drug for the control of myoclonic seizures. A controlled study would provide a better understanding of any possible aggravating role in certain forms of myoclonic-astatic epilepsy.
