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皮里病毒核衣壳蛋白(N)基因序列:水疱性口炎病毒N蛋白中的可能结构域

The sequence of the nucleocapsid protein (N) gene of Piry virus: possible domains in the N protein of vesiculoviruses.

作者信息

Crysler J G, Lee P, Reinders M, Prevec L

机构信息

Department of Biology, McMaster University, Hamilton, Ontario, Canada.

出版信息

J Gen Virol. 1990 Sep;71 ( Pt 9):2191-4. doi: 10.1099/0022-1317-71-9-2191.

Abstract

A number of independent cDNA clones of the Piry virus N gene message were identified and sequenced. From the resulting sequences and previously published data, we derived the sequence of the mRNA for this protein. Sequence similarities of the translated region of Piry virus with that of other viruses suggest that Piry virus is as distantly related to Chandipura virus as it is to the vesicular stomatitis viruses of Indiana and New Jersey serotypes. Based on the relative conservation of the amino acid sequence of the nucleocapsid protein of these vesiculoviruses, the N protein can be subdivided into at least three regions, possibly indicative of functional domains.

摘要

我们鉴定并测序了多个独立的皮里病毒N基因信使的cDNA克隆。根据所得序列和先前发表的数据,我们推导了该蛋白的mRNA序列。皮里病毒翻译区与其他病毒的序列相似性表明,皮里病毒与钱迪普拉病毒的亲缘关系和它与印第安纳州和新泽西州血清型水泡性口炎病毒的亲缘关系一样远。基于这些水泡性病毒核衣壳蛋白氨基酸序列的相对保守性,N蛋白可至少分为三个区域,这可能表明其功能域。

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